heroic dose
 n.— «An ounce in twenty-four hours, and a drachm at a dose, are heroic prescriptions, and not to be generally imitated.…In cases wherein the physician might be tempted to overstep nature with these heroic doses of opium, or tobacco, do not Dr. Physick’s tube and syringe, afford some hope of safety?» —“Observations and Facts on the Use of Tobacco in Tetanus &tc.” by S. Jackson in Northumberland, Penn. American Medical Recorder Oct., 1826. (source: Double-Tongued Dictionary)

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