So, can a sentence begin with the word so? Which ones? So is oftentimes used in place of therefore to conclude an explanation, but more people are using it as a general sentence-starter, in the same vein as well. Grant notes that while it may be grating to the ear, it’s not wrong, and it’s more productive not to peeve about it, but instead to record it and add it to the rest of the data we collect about our language. Ultimately, we learn about each other by doing so. This is part of a complete episode.